This article describes possible interactions with amoxicillin oral forms. Interactions can cause a drug to have a different effect on the body than expected. Interactions can occur due to medications, alcohol, or certain health conditions.
Amoxicillin comes as a chewable tablet, an oral tablet, an oral capsule, and an oral liquid suspension (a type of liquid mixture). Interactions of amoxicillin are expected to be the same across these forms.
Need a diagnosis or prescription quickly? For certain health conditions, Optum Perks offers personalized on-demand care with no appointment required. For $25, answer a few questions online and receive a diagnosis and treatment plan from a board certified healthcare professional in 15 minutes or less. Get started here.
Other drugs and amoxicillin
The drugs in the list below may interact with amoxicillin oral forms. This article doesn’t include all drugs that may interact with amoxicillin.
Drug classes or drugs that may interact with amoxicillin oral forms include:
- birth control pills:
- drug examples: desogestrel/ethinyl estradiol (Cyclessa and others), estradiol/levonorgestrel (Introvale and others)
- what might happen: can make birth control pills less effective
- allopurinol (Zyloprim):
- what might happen: can increase the risk of developing a skin rash
- methotrexate (Otrxup, Rasuvo, Trexall, Xatmep):
- probenecid (Probalan):
- what might happen: can increase the effect of amoxicillin
- sodium picosulfate/magnesium oxide/anhydrous citric acid (Clenpiq):
- what can happen: can make sodium picosulfate/magnesium oxide/anhydrous citric acid less effective
- warfarin:
- what might happen: can increase the risk of bleeding
Download the free Optum Perks Discount Card to save up to 80% on some prescription medications.
Questions about amoxicillin and interactions
Here you’ll find answers to some common questions about amoxicillin and possible interactions.
Is there an interaction between amoxicillin and Tylenol?
No, amoxicillin oral forms aren’t known to interact with acetaminophen (Tylenol). Acetaminophen, the active ingredient in Tylenol, is a common pain medication, and it’s usually safe to take with amoxicillin. (An active ingredient is what makes a medication work.)
If you have questions about taking amoxicillin and Tylenol, talk with your doctor or pharmacist.
Do amoxicillin and ibuprofen interact?
No, amoxicillin oral forms aren’t known to interact with ibuprofen (Advil, Motrin). Ibuprofen is used for pain and inflammation, and it’s safe to take with amoxicillin.
Talk with your doctor or pharmacist for more information about taking ibuprofen and amoxicillin.
Are there amoxicillin interactions with milk?
No, amoxicillin oral forms aren’t known to interact with foods, including milk. It’s safe to consume milk while taking amoxicillin. For more information about amoxicillin and foods, see the “Other interactions and amoxicillin” section below.
If you have questions about amoxicillin and milk, talk with your doctor or pharmacist.
When to avoid amoxicillin
Certain health conditions or other factors could increase some risks with amoxicillin oral forms. Because of this, doctors may not prescribe amoxicillin in these cases. These health conditions or other factors are called contraindications.
Here’s a list of amoxicillin’s contraindications:
- Past allergic reaction to cephalosporins: If you’ve ever had an allergic reaction to cephalosporin antibiotics, taking amoxicillin may cause a life threatening allergic reaction. Examples of cephalosporins include cephalexin and cefixime (Suprax).
- Past allergic reaction to other penicillins: If you’ve ever had an allergic reaction to other penicillin antibiotics, taking amoxicillin may cause a life threatening allergic reaction. Examples of other penicillins include penicillin VK and dicloxacillin.
- Past allergic reaction to amoxicillin: If you’ve ever had an allergic reaction to amoxicillin oral forms, taking it again may cause a life threatening allergic reaction.
Before you start taking amoxicillin, tell your doctor if anything listed above relates to you. They can recommend whether you should take amoxicillin.
Amoxicillin interactions with alcohol
Amoxicillin oral forms are not known to interact with alcohol.
If you drink alcohol, talk with your doctor about whether it’s safe to consume it while taking amoxicillin oral forms.
Other interactions and amoxicillin
Interactions can occur with foods, supplements, vaccines, and some lab tests. Below you can learn whether amoxicillin oral forms have these interactions.
The information below doesn’t include all other possible interactions with amoxicillin.
Amoxicillin interactions and food
Amoxicillin oral forms aren’t known to interact with foods. But this doesn’t mean interactions with foods can’t happen or won’t be identified later.
Because of this, talk with your doctor or pharmacist about any foods you should avoid while taking amoxicillin oral forms.
Amoxicillin and supplements
Before taking amoxicillin oral forms, tell your doctor and pharmacist about any herbs you take, as well as vitamins and supplements. Doing so may help you avoid interactions.
If you have questions about interactions that may affect you, talk with your doctor or pharmacist.
Amoxicillin interactions and vitamins
Amoxicillin oral forms aren’t known to interact with any vitamins. But this doesn’t mean interactions with vitamins can’t happen or won’t be identified later.
Because of this, ask your doctor or pharmacist before using any of these products while taking amoxicillin oral forms.
Amoxicillin interactions and herbs
Amoxicillin oral forms aren’t known to interact with any herbs. But this doesn’t mean interactions with herbs can’t happen or won’t be identified later.
Because of this, ask your doctor or pharmacist before using any of these products while taking amoxicillin oral forms.
Amoxicillin and vaccines
Amoxicillin oral forms may interact with the typhoid vaccine. This vaccination is given to help prevent typhoid fever in people traveling to certain countries.
Taking amoxicillin and receiving this vaccine may make the typhoid vaccine less effective.
Because of this, talk with your doctor or pharmacist before receiving the typhoid vaccine or any other vaccines while taking amoxicillin oral forms.
Amoxicillin and lab tests
Amoxicillin oral forms may interact with certain urine tests, which are used to check for glucose (sugar).
Taking amoxicillin and having this test may lead to false positive results.
Because of this, talk with your doctor or pharmacist before having any lab tests while taking amoxicillin oral forms.
Amoxicillin and cannabis or CBD
Amoxicillin oral forms aren’t known to interact with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But this doesn’t mean interactions can’t happen or won’t be identified later.
As with any drug or supplement, tell your doctor before taking cannabis with amoxicillin.
Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.
Health factors and amoxicillin
Certain medical conditions or other health factors may increase the risk of interactions with amoxicillin oral forms. Keep in mind that interactions could lead to side effects or affect how well the drug works. Before taking amoxicillin, tell your doctor about your health history. They’ll determine whether amoxicillin is right for you.
These health conditions or other factors might interact with amoxicillin oral forms:
For more details about allergic reactions, see the “When to avoid amoxicillin” section above.
Preventing amoxicillin interactions
You may be able to help avoid certain interactions with amoxicillin oral forms. Before taking this drug, you may want to discuss possible interactions with your doctor and pharmacist.
Things to consider include:
- Other medications you take. Your doctor or pharmacist can help you fill out a medication list.
- What to do if you’re prescribed a new drug while taking amoxicillin oral forms.
Taking amoxicillin exactly as prescribed can also help prevent interactions.
What to ask your doctor
If you have questions about amoxicillin and possible interactions, talk with your doctor.
Questions you may want to ask your doctor include:
- If I take amoxicillin and birth control pills, how can I manage the interaction?
- Do other drugs that could treat my condition have similar interactions?
- Should I tell you if I start taking another medication or supplement during my amoxicillin treatment?
Disclaimer: Optum Perks has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
